Sentence examples for binds to regulatory elements from inspiring English sources
In this study, we conduct a comprehensive genome-wide analysis of IRF5 recruitment in macrophages stimulated with bacterial lipopolysaccharide and discover that IRF5 binds to regulatory elements of highly transcribed genes.
This mechanism of regulation occurs primarily via the action of iron regulatory protein (IRP 1/2 which binds to regulatory elements in the 3′-untranslated or 5′-untranslated regions of FTH and CD71 mRNA, respectively [ 1– 3].
Transcription factors bind to regulatory elements upstream of transcription start sites and interact with other factors to create an abundant regulatory environment.
Reduction of DNA methylation may facilitate transcription through allowing transcription factors or co-activators to bind to regulatory elements (promoter or enhancer regions) [ 13- 15].
The activated Smads then collectively translocate into the nucleus, where they bind to regulatory elements on the promoter regions of their target genes to regulate gene transcription [ 24].
Activated IRFs form homodimers or heterodimers, translocate to the nucleus and bind to regulatory elements in the promoter regions of type I interferon genes, triggering transcription [ 7].
The gene transcription in eukaryotes is complex and is largely modulated by transcription factors that bind to regulatory elements within promoters.
2-ME-mediated induction of IFN promoter suggests that 2-ME might recruit transcription factors (proteins) that could directly bind to regulatory elements on the IFN promoter.
Their mode of action is to first recognize and then bind to regulatory elements located in the promoter region of their target genes, thereby activating or de-activating their transcription.
Second, we note the importance given to genome-wide ChIP experiments showing that, in ESCs, Oct4 can be found bound to regulatory elements at certain genes that are not expressed these genes become expressed upon differentiation.
By comparing wild-type AR binding in the absence and presence of its ligand agonist metribolone, we found that AR bound to regulatory DNA elements even when androgen levels were low via selective occupancy of the strongest binding sites, offering molecular evidence for active AR signaling in CRPC tumors [ 2].
