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Ttk69 binds to multiple regions in the introns and upstream of duf (Fig. 3V) at the approximate site of the rP298 P-element insertion (Ruiz-Gómez et al., 2000).
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The authors found 14% 'non-specific' cases where a primer/probe set can bind to multiple regions in the genome.
NF-κB directly binds to multiple sites on the nos2 promoter region in LPS-treated J774 cells (Fig. 6b).
Using chromatin immunoprecipitation assays, we showed that Gli2 bound to multiple regulatory regions in the Ascl1 gene, including promoter and enhancer regions during Gli2-induced neurogenesis.
The viral regulatory protein binds to multiple copies of the ACCN6GGT motif that occur in the long control region (LCR) of all HPVs [ 10, 11].
*Travelled to multiple regions within India.
Here we present a detailed examination of two divergent examples: 1) p53, which uses different disordered regions to bind to different partners and which also has several individual disordered regions that each bind to multiple partners, and 2) 14-3-3, which is a structured protein that associates with many different intrinsically disordered partners.
Chameleon behavior could be an important feature that enables one disordered region to bind to multiple partners.
What if a region used to bind to multiple partners uses different secondary structures and different amino acids?
Several groups have tested these overall ideas further via bioinformatics studies on collections of hub proteins, and these studies support the common use of disordered regions by hub proteins to bind to multiple partners [ 130- 134].
The flexible, disordered region may allow CheY6 to bind to multiple ligands.
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