ELC‐1 is a core factor of E3 ligase and binds to multiple substrate‐specific subunits, including VHL‐1, which has limited specificity for the degradation of substrate proteins.
The volume of the heparan sulphate chains greatly exceeds that of the integrins with which it cooperates, while the short cytodomain must bind to multiple cytoplasmic factors, despite being long enough to bind only one or two.
Mr. Nisbett ascribes these differences to multiple factors, including education, social philosophies and the environment.
The feeble U.S. response may be linked to multiple factors.
This transcription factor, as well as similar variants, bind to multiple binding motifs (Godoy et al. 2011).
We integrate lincRNAs into the molecular circuitry of ES cells and show that lincRNA genes are regulated by key transcription factors and that lincRNA transcripts bind to multiple chromatin regulatory proteins to affect shared gene expression programs.
Most Wnt proteins can bind to multiple Frizzleds and vice versa, suggesting redundancy in vivo.
Ten of these are significantly downregulated in differentiation, and all but two show a downregulation trend (Table S6), in agreement with the hypothesis that genes bound by multiple factors are active in ESCs and become repressed as cells differentiate (Chambers and Tomlinson, 2009; Kim et al., 2008; Orkin et al., 2008).
Smo activation appears to also shield the Gli proteins from the repressive effects of Sufu, which binds to Gli factors and inhibits their activity through multiple mechanisms.
Combinatorial gene regulation leads to a statistical tendency of multiple factors to bind to proximally located sites, a phenomenon we call TF "co-localization".
