Sentence examples for binds to multiple CDKs from inspiring English sources

Furthermore, we demonstrated for the first time that SGTP binds to multiple CDKs, which may perturb the CDK-mediated phosphorylation and cell cycle progression.

Aside from the various GTPases, we also made an interesting discovery that SGTP can bind to multiple CDKs.

CDKs activity can be regulated by cell cycle inhibitory proteins (CKI) that bind to CDKs or CDK-cyclin complexes.

Another level of cell cycle regulation is affected by the cdk inhibitors, which bind to cdk or cdk-cyclin complexes and inhibit their kinase activity.

p16, which binds to cdks 4 and 6 and prevents their association with the D-type cyclins, thus inhibiting the catalytic activity of the cdk-cyclin complex, is inactivated in over 80% of pancreatic cancers [ 40].

It binds to cyclin-CDK complexes to arrest cell cycle progression at G1 phase.

CDK is a member of serine-threonine kinase family because a cyclin binds to a CDK and starts the phosphorylation of its serine and threonine site [ 4, 5].

p27Kip1 is a cyclin-dependent kinase (CDK) inhibitor that binds to various CDK-cyclin complexes, inhibiting their activity and preventing progression of the cell cycle.

Activated p16ink4a binds to and inhibits CDK 4/6, which separated cyclin D1-CDK4/6 D1-CDK4/6

p27kip1 a member of the Cip/Kip family of cyclin-dependent kinase (Cdk) inhibitors, binds to Cdk2 (and other Cdks) and potently inhibits Cdk2 kinase activity [63].

It has been previously demonstrated that p27 overexpression causes G1 arrest due to the inhibition of multiple cdks, including cyclin E-cdk2 (48).