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Thus, the evolutionary time scales of ERV insertions and the appearance of the zinc-finger gene that binds to its unique sequences should occur at the same time.
RANKL binds to its unique receptor activator of NF-κB (RANK) [ 60], and the RANKL/ RANK pathway seems of crucial importance in osteoclastogenesis and the bone erosion process.
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Unlike most amino acids, which are aminoacylated onto their cognate tRNAs, Sec is synthesized from serine in a multi-step reaction while bound to its unique tRNA[Ser]Sec [3].
Moreover, a recent study showed that CREBH could bind to its unique response element (CREBHRE) in the target gene promoter to modulate transcription [ 10, 12].
Binding of IL-17 to its unique receptor results in activation of the adapter molecule TNF-receptor-associated factor 6 (TRAF6), which is required for IL-17 signaling [ 12].
It binds to a unique ligand, ICOSL, and does not bind to other ligands such as B7-1/B7-2 B7-1/B7-2 B7-1/B7-2
It has previously been reported that Nck binds to the unique domain of Lck via its SH3 domains, and that phosphorylation of Ser disrupts the interaction [ 23].
Previous observations that LAMP2A stabilization at the lysosomal membrane is regulated by glial fibrillary acidic protein which binds to LAMP2A through its unique carboxy-terminal domain at the cytosolic tail (Kaushik & Cuervo, 2012) support that LAMP2A and LAMP2B turnover have independent regulation.
Here, we report that ethaselen, a novel organoselenium compound with anticancer activity, specifically binds to the unique selenocysteine cysteine redox pair in the C-terminal active site of mammalian TrxR1.
This mAb binds to an unique epitope on HBsAg and potently suppress levels of HBsAg and HBV DNA for several weeks in HBV transgenic mice (Zhang et al., 2016).
The CART receptor has yet to be identified, but there is significant evidence that CART binds to a unique Gi/Go-coupled.
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