Sentence examples for binds to its response from inspiring English sources

After ligand binding, VDR heterodimerizes with RXR and binds to its response elements (vitamin D response elements, VDREs) within its target gene promoters.

In the nucleus, CAR only binds to its response elements after forming heterodimers with the retinoid X receptor (RXR).

In active repression, NR2F2 binds to its response element, while in trans-repression NR2F2 inhibits transcription in the absence of its cognate binding motif or independent of nucleic acid binding [40].

FOXO1 enhances IL-1 β expression when the NF- κB dimer simultaneously binds to its response elements.

After activation, the AR ligand complex migrates into the nucleus and binds to its response element, which together with coactivators initiates transcription and cellular responses (Brinkmann et al. 1999; Veldscholte et al. 1992).

In order to examine whether the NF- κB pathway mediated the decrease in P-gp expression, we used a NF- κB response element luciferase gene reporter assay, in which luciferase activity increases as NF- κB binds to its response element.

p53 can bind to its response element present in miR-145 promoter and can up regulate miR-145 expression.

NFκB activation relies on stimulus-induced IκBα phosphorylation and proteasomal degradation, allowing free NFκB to translocate into the nucleus and to bind to its response element on the DNA [ 13].

Thus, OCT4 specifically binds to its putative response elements in the miR-125b-1 miR-125b-1 miR-125b-1trong evidence that miR-125b-1 can be directly regulated by OCT4.

The heterodimer binds to its specific LXR response elements, a DR4 direct repeat element composed of two half-sites 5′-AGGTCA-3′ (Jakobsson et al. 2012).

The traditional core of an endocrine system consists of an endocrine gland, the hormone it secretes, a responding tissue containing a specific receptor to which the hormone binds, and an action that results after the hormone binds to its receptor, termed the postreceptor response.