Sentence examples for binds to its cellular from inspiring English sources
It is important to note that TNF- α binds to its cellular TNF- α receptor 1 (TNFR1), which triggers signaling cascades that activate NF- κB and AP-1 transcription factors [ 53, 54].
We report here the design and synthesis of functionalized trisaccharides modeled after an α-helical 15-mer peptide region of p53 which binds to its cellular regulator MDM2.
When the PA heptamer binds to its cellular receptor, ANTXR, the interaction inhibits channel formation, significantly stabilizing PA complexes by ∼2 pH units [15], [17].
PA (83 kDa) first binds to its cellular receptors, CMG2 and/or TEM8, and then furin or furin-like proteases cleave PA and release the N-terminal 20-kDa fragment [13] [17].
When the iron transferrin complex binds to its cellular receptor (TfR), iron enters cells and the soluble extracellular domain of TfR is liberated into the circulation [ 17].
Briefly, as illustrated in Fig. 1, HBV virion binds to its cellular receptor, sodium taurocholate cotransporting polypeptide (NTCP), on the surface of hepatocyte and is subsequently internalized by macropinocytosis.
This mutant molecule, lacking the head, motor domain that bind actin but containing the neck and tail domains, is expected to bind to its cellular targets and function as dominant negative by blocking wt myosin binding.
Binding of HCV to its cellular receptors is followed by receptor-mediated endocytosis and viral uncoating, which leads to the release of the HCV genome into the cytoplasm to serve as a messenger RNA for the HCV polyprotein precursor.
As microRNA has to bind to its target gene for regulating cellular characteristics, we subsequently tested the expression of two direct target genes of miR-17, namely TCF3 and Smurf1.
In case of cellular damage or stress conditions, antitoxins are degraded, allowing the free toxin to bind its cellular target.
Although iota-carrageenan binds to the cellular surface only weakly, its antiviral effect might be due to coating of cellular structures usually required for viral binding to its cognate receptors.
