Sentence examples for binds to hypoxia responsive from inspiring English sources

HIF-1α is imported into the nucleus, dimerizes with HIF-1β and binds to hypoxia responsive elements (HREs), enabling transcriptional activation of more than 70 genes that help cells to cope and survive under hypoxia [1], [6], such as the vascular endothelial growth factor (VEGF).

The so-formed HIF-1 complex binds to hypoxia responsive elements of target genes, thereby regulating their transcription.

The HIF complex binds to hypoxia responsive elements (HREs) in gene promoters, thereby inducing the transcription of genes important for the adaption to low oxygen concentrations.

The tumour-related expression pattern of CA IX is principally determined by a strong activation of CA9 gene transcription via a hypoxia-inducible factor (HIF), which binds to hypoxia responsive element (HRE) localised in the minimal CA9 promoter proximal to transcription start site at −10/−3 position (Wykoff et al, 2000).

Subsequently, HIF1 α translocates into the nucleus and forms the transcriptionally active HIF1 complex after dimerization with HIF1 β, which then binds to hypoxia responsive elements (HREs; 5′-NCGTG-3′) within the promoter region of target genes and activates their expression [ 11].

In reduced oxygen conditions, HIF-1α binds to hypoxia-responsive elements which, in turn, stimulate the transcriptional coactivators CREB-binding protein and induces transcription of various target genes involved in tumor invasion, cell survival, and angiogenesis.

The heterodimers then binds to hypoxia-responsive elements (HREs) in the DNA and regulate hypoxia-specific target genes, one of which is EPO.

In the hypoxic environment, HIF-1 α dimerises with HIF-1 β and binds to hypoxia-responsive elements (HRE) within the nucleus.

It then binds to hypoxia-responsive elements (HREs) on the promoters of target genes that are often involved in modulating cell survival, motility, and metabolism [ 88, 89].

Hypoxia-inducible factor-2 α accumulates in the presence of hypoxia, forms a heterodimer with HIF-1 β and binds to hypoxia-responsive elements.

HIF binds to hypoxia-responsive elements (HREs) located in the promoter/enhancer regions of numerous hypoxia-inducible genes to initiate various adaptive responses to hypoxia, such as anaerobic metabolism, erythropoiesis and angiogenesis (Kaelin, 2002; Roberts & Ohh, 2008).