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The newfound gene's product is a protein that binds to different sites along the DNA, signaling the cell to activate the nearby genes.
Till date many anticancer toxins are discovered that binds to different sites of actin.
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Thus, interference can be low if two compounds bind to different sites of the substrate binding site [ 31].
Epothilones and paclitaxel compete for the same binding pocket on β-tubulin; however, epothilones and the taxanes bind to different sites on β-tubulin.
Based on our results, which demonstrate that the CpG and non-CpG PS DNA have the same stoichiometry with TLR9 but with different binding affinity, it implies that the CpG and non CpG DNA might bind to different sites of TLR9.
More interestingly, docking simulations reveal that some of the oxazolxanthone derivatives bind to different sites in the enzyme.
Here we present results that show that PS and PREGAS bind to different sites in the ATD of the GluA2 subunit, which when combined with previous results from our lab, now identifies two binding domains for each neurosteroid.
We have designed and synthesized a new fluorescent probe, a testosterone substituted at the 6β- position with a fluorescent deazaflavine moiety which is able to inhibit to the same extent the hydroxylation of compounds known to bind to different sites in the CYP 3A4 active site.
Carrageenan and glycan bind to different sites on AFAL.
This result suggests that the two peptide ligands bind to different sites in the integrin.
By using motifs of fixed length, these methods implicitly assume proteins bind to different sites in the same structural configuration.
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