Very surprisingly, we have found that, unlike DB293 and synthetic polyamides that bind to mixed DNA sequences as dimers, DB1255 binds to certain GC-containing sequences in the minor groove as a monomer, and the binding is very dependent on the dithiophene group.
In general, Nrf2 is transferred into the nucleus and binds to certain regions of DNA in a sequence-independent manner [ 13].
Illuminating them with blue light leads to an influx of calcium ions, just as it does in the neurons; in the kidney cells, this does not trigger an electrical pulse but allows a so-called transcription factor, NFAT, to move into the cells' nuclei, bind to certain DNA sequences called promoters, and thus activate certain genes.
Transcription factors (TFs) are proteins, which bind to certain short sequences (motifs) in the regulatory regions (promoters, enhancers, silencers) of genes.
These results suggest that the GBD also binds to certain variable regions of LigA and LigB.
OPN binds to certain CD44 variants and integrin receptors [36], [37].
A remaining question is why HuR selectively binds to certain genes containing AREs.
FGFR5 binds to certain FGFs, as do the conventional FGFRs, but it does not bind to FGF1, which is also recognized by all of the other FGFRs [ 1].
While macromolecules smaller than ∼40 kDa can passively diffuse through these pores, most proteins with intranuclear function undergo active but selective transport mediated by nuclear import and export receptors that recognize and bind to certain short amino acid nuclear localization sequences (NLSs) and nuclear export sequences (NESs), respectively.
This phosphorylated form of p53 can be bound to certain target genes involved in apoptosis induction.
