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In general, Nrf2 is transferred into the nucleus and binds to certain regions of DNA in a sequence-independent manner [ 13].
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As mentioned above, the picture we have in mind is that proteins such as H-NS, HU, FIS etc. bind to certain regions of the chromosome and give it a compact local structure such that the chromosome consists of a chain of compact units.
Identification of the proteins bound to certain regions of the genome can be difficult but the engineered DNA-binding molecule-mediated chromatin immunoprecipitation method (enCHIP) developed by the Fuji lab was able to use the dCas9 fused to a protein tag to purify specific regions of the genome [ 108].
These results suggest that the GBD also binds to certain variable regions of LigA and LigB.
To mark such internal regions along chromosome arms in the same cell background, we analyzed live UMUC3 cells transiently transfected with HP1α, a non-histone protein that binds to certain heterochromatin regions [ 33].
CCAAT/Enhancer Binding Protein β (C/EBPβ) belongs to the C/EBP leucine zipper domain-containing family of transcription factors (Fig. 1). 1, 2 This intronless gene product binds to certain genomic regulatory regions either as a homodimer or as a heterodimer with other molecules, including other members of the C/EBP family.
Governed by the binding free energy of a protein-DNA interaction, some proteins bind more strongly to certain regions of the DNA than the other regions[ 7].
OPN binds to certain CD44 variants and integrin receptors [36], [37].
A remaining question is why HuR selectively binds to certain genes containing AREs.
FGFR5 binds to certain FGFs, as do the conventional FGFRs, but it does not bind to FGF1, which is also recognized by all of the other FGFRs [ 1].
The Yemeni government periodically restricts visits to certain regions.
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