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It's possible that BIA 10-2474 drug has completely unexpected effects because it binds to another target besides FAAH, molecular pharmacologist Stephen Alexander of the University of Nottingham in the United Kingdom said in a statement distributed by the Science Media Center (SMC) today; such "off-target" interactions might only become dangerous with more extensive exposure.
On the other hand, docetaxel binds to another target, TUBB1, instead of BCL2, which stabilizes microtubules and prevents depolymerization from calcium ions, decreased temperature and dilution, preferentially at the plus end of the microtubule.
Another very interesting finding was that at much lower concentrations, compound 4p showed high cytotoxic activity on breast tumor cells, however this effect was also well pronounced on normal cells which is probably due to the fact that this compound binds to another target rather than the Eg5 motor protein.
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In novel drug design, compounds are usually engineered to bind to a specific target, with the assumption that one drug binds to one target to treat one condition.
Some radioligands may produce radiometabolite(s) that binds to the target receptor.
Pum1 binds to its target mRNAs in 2i.
The target turnover might be another reason, as the FXa concentration is decreased when slow on‐rate compounds binds to the target.
One arm of the antibody activates T cells and another arm binds to a tumor target.
MiR27b binds to, among others target, cyclin T1 3′UT1.
Phosphorylated Smad2 acts as a transcription regulator and binds to target genes to induce transcription.
miRNA binds to target mRNA by imperfect complementarity, causing either mRNA degradation or translation inhibition.
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