Reporter and in vivo DNA-binding assays revealed that CEBPD directly binds to and activates CASP8 reporter activity.
One such Cdk1 substrate, Cdh1, binds to and activates the APC/C ubiquitin ligase – this activation is attenuated by Cdk-mediated phosphorylation of Cdh1.
Indomethacin, a nonsteroidal anti-inflammatory drug, binds to and activates the transcription factor peroxisome proliferator-activated receptor gamma (PPAR-γ), which is crucial for adipogenesis [ 126].
To assess the function of this gene, a screen of binding proteins was performed, which showed that G72 binds to and activates d-amino acid oxidase.
ATX binds to, and activates, protein kinase C (PKC) isozymes and shows anti-proliferative activity against human cancer cell lines.
Calcium binds to and activates calmodulin, a primary and highly conserved calcium-binding protein, that in turn binds to and activates effector calmodulin-dependent enzymes, such as calcineurin (Fox and Heitman 2002; Cyert 2001, 2003).
Activated (GTP-bound) Tem1 then binds to and activates the Cdc15 kinase, a critical component of MEN, which leads to activation of the phosphatase Cdc14.
Fig. 4 OsWRKY11 directly binds to and activates the CHITINASE 2 promoter.
Brain-derived neurotrophic factor (BDNF), a neurotrophin, binds to and activates its specific receptor tyrosine kinase, TrkB.
In the present study, we demonstrated that c-Jun directly binds to and activates at least 4 BCLM-associated genes, including ANGPTL4, MMP1, PTGS2 and TNC.
Moreover, stimulation such as ATP induces mitochondrial dysfunction resulting in mtDNA release into the cytoplasm, where it binds to and activates the NLRP3 inflammasome.
