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In phloem sap, Cd binds to an unknown 13 kDa protein and SH-compounds (Kato et al. 2010).
B7-H3 binds to an unknown receptor expressed on activated CD4+ and CD8+ T cells.
Because the mH2A antibody binds to an unknown epitope in the GV, immunofluorescence of transplanted nuclei was not possible.
It is a pro-angiogenic secreted ribonuclease that binds to an unknown receptor leading to endocytosis and pro-angiogenic effects in the cell nuclei, including proliferation (Moroianu and Riordan, 1994).
Secondly, this function of BCL9 depends on β-catenin, but also on its C-terminus, implying that this conserved part of the protein binds to an unknown ligand that is important for its Wnt-related function.
By using an ERCC1-XPF deficient cell line, Bhagwat et al. discovered that the 8F1 antibody binds to an unknown cross-reactive protein that migrates at a molecular weight similar to ERCC1 on SDS-PAGE gels but the molecular identity for this cross-reactive target was unknown [ 19].
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However, we do not exclude the role of HIF1α in Vegf induction during luteinization, because HIF1α may regulate Vegf expression at different time points of luteinization process, or bind to an unknown promoter or enhancer region of Vegf gene undergoing luteinization in GCs.
More than 95 99% of the metal is normally bound to an unknown organic compound(s), which is in excess to the metal in the sample.
"We were fairly certain it was XPB because other researchers had found triptolide to bind to an unknown protein of the same size, but they weren't able to identify it," Liu said.
Binding to an unknown target can be influenced by cell absorption and transport, additional protein binding, secondary target interactions, drug metabolism, etc.
Interestingly an overlapping region of L2, residues 13 31, has been shown to bind to an unknown receptor on the surface of SiHa, CaSki, and HeLa cervical epithelial cells [33].
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