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TAND2 binds to an interface on the convex surface of TBP that is crucial for TFIIA binding.
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Our focus has been on the design and construction of biomimetic interfaces, where a lipid bilayer or a hybrid bilayer membrane can be bound to an interface.
Notably, orange-G binds to a flat interface along the fibril axis in a manner that appears to stabilize the fibrils.
Orthosteric binding sites in 5-HT3AB recouldrs could theoretically exist at A+A−, A+B−, B+A−, and B+B− interfaces, but the majority of 5-HT3 receptor-competitive ligands only bind to an A+A− interface.
Recent mutagenesis and cysteine modification studies indicate that agonists and antagonists bind to an A A interface both in human homomeric 5-HT3A and heteromeric 5-HT3AB receptors which is consistent with their observed identical competitive pharmacologies.
Thapisgargin, a highly cell-penetrant sesquiterpene-lactone that once inside cells potently and specifically inhibits mammalian SERCA, binds to a cavity at the interface of the M3, M5 and M7 helices [19] [20].
Palonosetron was also proposed to bind to a B+A− interface.
The peptide binds to a deep pocket formed at the interface of the variable domains of the light and the heavy chain, mainly through hydrophobic interaction to aromatic residues and hydrogen bonds to acidic residues.
Consumers that are bound to an RPC-style interface are more likely to be negatively impacted by change.
(Nada and Furukawa, 2012), in real world systems, AFPs bind to an ice-water interface rather than ice crystal planes alone, thus earlier AFP simulations are unable to provide complete mechanistic details of the AFP-ice interaction.
One c-di-GMP binds to the interface of STING dimer with a unique mode.
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