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It is possible that mutation of the PTB site I might be insufficient to permit splicing in S100 complementation, for example, in a scenario in which PTB binds to additional sites in IgM M1-M2 to silence splicing.
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CtrA also binds to four additional sites downstream of the S6 TSS suggesting a complex mechanism of autoregulation.
In contrast, while 90%% of Abd-A peaks overlap with Abd-B peaks, Abd-B clearly binds at additional sites as only 53 % of Abd-B peaks overlap Abd-A peaks (Fig. 1b).
However, another possibility is that this specific N-glycosylation site is used to enable Ltbp-4S to bind to additional unknown factors.
The distinct water sites localized in the covalent intermediate active site in the absence of lactose are also observed with lactose present; when lactose binds, an additional site also forms [WAT_3], which indirectly is involved in interactions with lactose.
There is currently no urgent need to select additional sites".
CHAD binds to two sites on type-2 collagen.
The docking analysis is consistent with the findings that GF neither binds to the colchicine site [ 12] nor the vinblastine site in tubulin (Additional file 1, Figure S5; Additional file 1, Table S5).
OsSND2 binds to the SNBE sites in the OsMYB61promoter.
5′-Inosinate binds to an adjacent site close to the binding site for glutamate.
For those selected TFs, a search of motif similarity matches, by using STAMP tool [ 40], shows proteins do not bind to the same sites (Additional file 1, Figure S2 and Additional file 3). Figure 2 and Additional file 1 Figure S3 present the clustering of the t-values (histone modification activities) for ORF and promoter, respectively.
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