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REST is unique: it binds to a unique sequence that allows identity of the binding sites both bioinformatically and by ChIP; the gene targets represent a large set of proteins that are essential for terminal neuronal differentiation, a specific transition during differentiation; and REST is present in ESCs, where these targets are repressed, and minimally expressed at terminal differentiation.
The CART receptor has yet to be identified, but there is significant evidence that CART binds to a unique Gi/Go-coupled.
In theory, each unique hexapeptide binds to a unique protein recognition site.
It binds to a unique ligand, ICOSL, and does not bind to other ligands such as B7-1/B7-2 B7-1/B7-2 B7-1/B7-2
GATA3 binds to a unique set of enhancer sites in Th2 cells and this is associated with Th2-polarized expression of the associated genes.
Like trastuzumab, pertuzumab is a HER2-targeted humanized monoclonal antibody; however, it binds to a unique epitope in the dimerization domain and has a complementary mode of action to trastuzumab [ 8, 9].
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This mAb binds to an unique epitope on HBsAg and potently suppress levels of HBsAg and HBV DNA for several weeks in HBV transgenic mice (Zhang et al., 2016).
Recently, specific HIF2α inhibitors that bind to a unique cavity in HIF2α were developed [55, 56].
In principle, an aptamer can specifically recognize and bind to a unique ligand, leading to a structural change of an aptamer.
In addition to using firewalls for this purpose, Wu et al. [20] also employ subnetting (i.e., each virtual network is bound to a unique subnet) in order to provide an additional layer of security against unauthorized information disclosure.
Peptide or small molecule ligands that bind to a unique region of a protein can be used for orienting the protein and modulating its activity through specific ligand-protein interactions on a solid support [11] [13].
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binding to a unique
binds to a specific
binds to a central
binds to a ribosome
binds to a pre-existing
binds to a cytosolic
binds to a short
binds to a GU-rich
binds to a different
binds to a lipopolysaccharide-binding
binds to a wide
binds to a conformational
binds to a precise
binds to a proline-rich
binds to a broad
binds to a pseudo-palindromic
binds to a cell-surface
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