Together, our data establish that TRPM3 is activated when PS binds to a specific binding site on a protein.
A detailed DbTF annotation guideline document is provided in Supplementary Material 2. A DbTF is a DNA binding transcription factor that binds to a specific DNA sequence and regulates the transcription of the associated gene.
Subsequently, ACTH increases cortisol release from the adrenal glands, which then binds to a specific carrier – cortisol-binding globulin (CBG) – that is synthetized by the liver and to albumin in order to reach the target tissues.
Subsequently, ISGF3 translocates to the nucleus and binds to a specific transcription factor binding-site (TFBS), the IFN stimulated response element (IRF/ISRE), which in turn activates transcription of several hundred IFN-responsive genes.
DT binds to a specific receptor, the heparin-binding epidermal growth factor-like precursor, enters into the cytosol by receptor-mediated endocytosis, and translocates from acidified endosomes to the cytosol, where it inactivates eEF-2 [11] [11].
Nutritional starvation induces expression of the ste11+ gene, which encodes a DNA-binding protein belonging to the high-mobility group (HMG) family and binds to a specific DNA sequence (TTCTTTGTTY) called the TR box [13].
Each domain binds to a specific matrix component or to a specific site on a cell.
When the embryo's DNA binds to a specific pattern, that segment of the chip will change color (from, say, red to green) -- signaling an aberrant gene sequence.
A drug of this type is the antifungal agent amphotericin B, which binds to a specific molecule (ergosterol) found in fungal cells.
Early this year, Dr. Karsenty's team published a study demonstrating that in mice a protein called osteocalcin, which is produced by bone-forming cells called osteoblasts, binds to a specific receptor on cells of the testes.
It is well known that the engrailed-2 (EN2) protein, a biomarker for prostate cancer, strongly binds to a specific DNA sequence (5′-TAATTA-3′) to regulate transcription.
