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Thalidomide binds to a protein known as cereblon, which normally is active during embryonic development.
Herceptin, also known as trastuzumab, binds to a protein on the surface of breast cancer cells called HER2.
VWF binds to a protein complex made up of the glycoproteins Ib, IX, and V on the surfaces of platelets.
At its target tissues, the free hormone penetrates the cell surface and then binds to a protein known as an estrogen receptor in the cytoplasm of the cells.
To get around this, the researchers designed a radioactive tracer molecule called [11C]UCB-J, which binds to a protein called SV2A, which is found exclusively in synaptic vesicles at nerve terminals, and which regulates the release of neurotransmitter molecules from them, a vital step in brain signalling.
In May two groups working independently, one headed by Mark Estelle from Indiana University and the other headed by Ottoline Leyser from the University of York, Eng., reported that auxin binds to a protein complex called SCFTIR1 and that, once bound, the complex acts to target a specific set of proteins, called Aux/IAAs, for degradation.
Similar(26)
In a live lobster the molecules of astaxanthin are bound to a protein molecule.
Quantum Dot, based in Hayward, Calif., introduced its first product to drug researchers in November: a metallic crystal that is bound to a protein called streptavidin.
Later, Dr. van Kooyk's team learned that scientists from Bristol-Myers had found what was apparently the same protein bound to a protein on the surface of H.I.V. but had not linked it to dendritic cells.
These bind to a protein called CD20 that sits on the surface of cancer stem cells.
Fourth, the peptide must be bound to a protein.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com