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1H 15N chemical shift perturbation data showed that recombinant CBTX binds to a peptide derived from the α7 subunit of the Torpedo acetylcholine receptor (AchR) with high affinity.
AvrB binds to a peptide fragment of its host virulence target in a similar manner as fic binds peptide substrate.
The "T Cell Receptor Signalling Pathway" is a pathway activated when a T Cell Receptor binds to a peptide from a foreign organism.
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Class B G-protein-coupled receptors are exciting drug targets, yet the structure of a complete receptor bound to a peptide agonist has remained elusive.
Using NMR, we have solved the three-dimensional solution structure of an extended construct of the second PDZ domain of MAGI-1 (MAGI-1 PDZ1) alone and bound to a peptide derived from the C-terminus of HPV16 E6, and we have characterized the changes in backbone dynamics and hydrogen bonding that occur upon binding.
In order to investigate the molecular determinants of the Co-IP results, particularly the GR LBD-21OH-6,19OP inabilito to recruit TIF2, we carried out further MD simulations of GR LBD-ligand complexes bound to a peptide corresponding to the TIF2 coactivator.
The crystal structure of opsin bound to a peptide derived from the C-terminal of transducin suggests that R3.50 (of the DRY motif) is important for the interaction with G protein while the D3.49 is important for the transition between inactive and active states [43].
We show that all Pellinos bind to a peptide derived from this region of IRAK1, but with different affinities.
Inspection of the crystal structure of the ternary complex of PFTase bound to a peptide substrate and isoprenoid analogue reveals extensive contacts between the isoprenoid and the peptide.
Ideally, a computational model could be developed to predict whether a PRM will bind to a peptide given their primary sequences.
To do this, drugs must exist in a multivalent form expressing several epitopes and likely therefore bound to a peptide or protein molecule.
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