As the mobile liquid phase slowly percolates through the stationary column, each As III) solute progressively binds to a multitude of Fe III) sorption sites favoring As III) oxidation.
MIP controls the intracellular levels of PI[ 3, 5]P2, which in turn binds to a multitude of proteins [ 28- 30], therefore working as a principal molecule in the coordination of intracellular networks [ 28, 31].
Aptamers are an interesting alternative to antibodies in pharmaceutics and biosensorics, because they are able to bind to a multitude of possible target molecules with high affinity.
Biochemical work studying methyl-CpG binding proteins over the past twenty years has revealed that in addition to specifically associating with methylated CpG dinucleotides, these proteins also bind to a multitude of different chromatin modifying enzymes, including histone deacetylases and histone lysine methyltransferases.
Another way in which p300/CBP is able to respond to signaling pathways is due to the ability of p300/CBP to bind a multitude of different proteins, using its various protein-interacting domains.
These novel diagnostic agents produce high contrast images due to their fast clearance from the bloodstream and healthy tissues, can be evolved to bind a multitude of cancer biomarkers, and are easily functionalized by site-specific bioconjugation methods.
Moreover, ER binds to chromatin with a multitude of transcription factors (ER-cooperating factors) that influence transcriptional activity of ER and ultimately affect the outcome of anti-estrogen therapies (Carroll et al. 2005; Laganiere et al. 2005a, b; Cheng et al. 2006; Hurtado et al. 2011; Kong et al. 2011).
These proteins are able to bind a multitude of different signaling proteins including kinases, phosphatases and transmembrane receptors and play a major role in modulating a wide range of regulatory processes such as mitogenic signal transduction, cell cycle control, ion channel regulation, and apoptosis [36].
A striking feature of the 14-3-3 14-3-3 14-3-3heir ability to bind a multitude of functionally diverse signaling proteins, iscluding kinases, phosphatheir, abilitynsmembrane receptors.
One member of each subgroup partners to form a heterodimeric complex that binds to the promoter of a multitude of target genes.
