Sentence examples for binds to a large from inspiring English sources
At the biochemical level, the KD binds to ATP as the only ligand, whereas the PBD binds to a large spectrum of binding targets, such as Plk1-binding proteins and physiological substrates (Park et al. 2010).
Larger proteins can enter the mitochondrion if a signaling sequence at their N-terminus binds to a large multisubunit protein called translocase of the outer membrane, which then actively moves them across the membrane.
In vitro gel shift and DNase I foot-printing analyses with purified CovR suggest that CovR binds to a large region surrounding the -10 region of the P1882.
As a result, it binds to a large number of partners, usually by recognizing phosphoserine or phosphothreonine motifs.
First, a length of DNA is copied to make a messenger RNA (or mRNA) molecule, which then binds to a large molecular complex called a ribosome.
We demonstrate that NEUROD2 binds to a large number of target genes with prominent roles in radial migration, layer-specific differentiation and axon pathfinding of cortical projection neurons.
It has recently been demonstrated that FLICA covalently binds to a larger subunit of active caspases produced by proteolytic cleavage of the proenzyme [ 44, 45].
pVHL binds to a larger amount of TLX in early hypoxia than in normoxia, which may be a mechanism for a rapid stabilization of a partially hydroxylated pool of HIF-α.
A statistically relevant hit to a binding site bound to a large ligand with smaller cognate similarity might offer equal or greater relevant functional clues as a hit to a smaller ligand with greater cognate similarity.
These proteins differ from classical C-type lectins in that they lack the calcium and sugar-binding loop and instead bind to a large variety of proteins and receptors involved in hemostasis, including coagulation factors IX and X and various blood platelet receptors [ 72].
Alternatively, the crystal structures of several orphan receptors such as HNF4 were found to have a phospholipid constitutively bound to a large ligand binding pocket [ 5, 6].
