Despite the antigenic variation, distinct Opa proteins can bind to a domain common to several human carcinoembryonic antigen-related cell adhesion molecules (CEACAMs) (Virji et al., 1996b; 1999).
In fact, Nck2 associates with numerous receptor tyrosine kinases [ 17, 50- 54] through its SH2 domain and using its third SH3 domain, it binds to a LIM domain in PINCH (Particularly Interesting Cys-His-rich Protein) [ 55].
Cdc42 binds to a CRIB domain adjacent to the PDZ domain, increasing the affinity of the Par-6 PDZ for its carboxy-terminal ligand by ∼13-fold.
The SH2 domain of SOCS-1 binds to a JH1 domain of JAK2 and inhibits the phosphorylation of JAK2, thus downregulating the JAK/ signal transducers and activators of transcription (STAT) pathway (Narazaki et al, 1998; Yasukawa et al, 1999).
Among those, we determined that peptide aptamer 72 binds to a central domain on A20.
Rapamycin binds to a specific domain of mTOR and FKBP12 to form a sandwich-like structure that confers an unusually high specificity for rapamycin [61].
FADD contains another conserved protein interaction domain known as Death Effector Domain (DED) that binds to an homologous domain in caspase 8 leading to its activation.
FADD, in turn, contains a death effector domain that binds to an analogous domain repeated in tandem within the zymogen form of procaspase-8, forming the so-called death-inducing signaling complex (DISC), made up of Fas/CD95, FADD and procaspase-8 [20], which drives cells to apoptosis.
We showed that PAX3-FKHR binds to a paired-domain binding-site in the CPT1A promoter region, indicating that CPT1A is a novel transcriptional target of PAX3-FKHR.
In agreement, a yeast two-hybrid screen showed that SV2 binds to a PDZ-domain containing novel splice variant of the glutamate receptor-interacting protein [18].
