Zipcode binding protein 1 (ZBP1), which binds to a conserved 54-nucleotide region in the 3'-UTR of β-actin mRNA, prevents the mRNA from being used for translation, but again like hnRNP K, upon phosphorylation of Tyr396, it frees the bound mRNA, allowing it to be used for translation [19].
Two specific long-range interactions clamp the two halves of the domain together: a two-Mg2+-coordinated adenosine-rich corkscrew plugs into the minor groove of a helix, and a GAAA hairpin loop binds to a conserved 11-nucleotide internal loop.
In these species, ClgR binds to a conserved sequence upstream of clpP and activates transcription of this gene.
In order to assess the contribution of E-cadh to catenin localization, we immuno-stained embryo for β-catenin (β-cat), which binds to a conserved region of conventional cadherins [12], in control and Chp morphant embryos.
The transcription factor CBF2 binds to a conserved cis-regulatory element, the CRT/DRE, which contains a CCGAC core motif, presented in CBF target gene promoter regions, and thus activates transcription of the CBF regulons.
HrpX is an AraC-type transcriptional activator that binds to a conserved DNA motif [plant-inducible promoter (PIP) box; consensus: TTCGC-N15-TTCGC], which is present in the promoter regions of most hrpX-regulated genes [33], [35].
Rapamycin binds to a highly conserved cytoplasmic receptor FK506-binding protein-12 (FKBP12).
Ro60 binds to a highly conserved site on the lower stem of Y RNAs [11], [12], [29], while La interacts with the 3' polyuridine tail [28], [29].
Ro60 protein binds to a highly conserved site on the lower stem of the Y RNAs [11], [12], [13], which is distinct from the domain required for DNA replication [10].
E2C is a homodimeric β-barrel protein (36− 41), which binds to a highly conserved pseudopalindromic target site.
KLHL3 binds to a highly conserved degron motif located within the C-terminal non-catalytic domain of WNK isoforms.
