Sentence examples for binds to a consensus from inspiring English sources

The Fur protein is a homodimer that, upon binding its co-repressor Fe2+, binds to a consensus sequence in the promoter of Fur-regulated genes, repressing their transcription [ 27, 28].

In DNA binding gel shift assays, the in vitro synthesized ER77 binds to a consensus vitellogenin A2 oestrogen-response element.

Nanog-TAT can be readily expressed in and purified from E. coli and binds to a consensus Nanog DNA sequence.

pSTAT1 is a transcription factor that binds to a consensus sequence termed Gamma Activation Sequence or GAS (TTC n2-4 GAA) [44].

Activated STAT1 and STAT2 monomers are then disassociate from the receptor and form a heterodimer that interacts with interferon regulatory factor 9 (p48) to form an active transcription complex called IFN-stimulated gene factor 3. This complex translocates into the nucleus and binds to a consensus DNA sequence to initiate antiviral gene transcription.

With high affinity and specificity, homodimeric SRF binds to a consensus cis-element known as a CArG box, with the sequence of CC(A/T 6GG [ 12, 13].

The bcl-2 gene is a direct target of BP1 since: (i) BP1 protein bound to a consensus binding sequence upstream of the bcl-2 promoterter in vitro.

The basic region, which consists of approximately 17 amino acids and is located at the N-terminus of the domain, is a DNA-binding region that allows HLH proteins to bind to a consensus hexanucleotide E-box (CANNTG) [ 5, 6].

We present here a 1.96 Å structure of Aart, a designed six-zinc finger protein, bound to a consensus DNA target site.

Puf3p is also known to bind to a consensus motif in the 3'UTR of many mRNAs encoding mitochondrial proteins [16] [16].

In AngII-infused rats for 3 days, a nuclear blue staining, indicating active Smad complexes that bind to a consensus Smad sequence in DNA, was observed in many vascular cells, while few positive cells were found in control, simvastatin or atorvastatin treated samples (Figure 2C).