Sentence examples for binds to a conformational from inspiring English sources

Monoclonal antibody MAb3-2C2 to P450arom specifically binds to a conformational epitope and suppresses the enzyme activity in a dose-dependent manner.

The monoclonal antibody 2D7 binds to a conformational epitope on CCR5, and inhibits Ca2+ flux induced by CCL5.

Detection with protein-A was also successful, pointing to a generally correct folding of the VH, since protein-A binds to a conformational epitope on the opposite face of the former dimerization interface between VH and the variable light domain VL [26].

The Ptx MAb (3F10) binds to a conformational epitope in the PtxA subunit (16 ).

W6/32 is a prototypic anti-MHC class I antibody that binds to a conformational epitope on MHCI heavy chains upon their association with β-2-microglubulin and the peptide [ 36, 41, 55].

Gantenerumab, in contrast, binds to a conformational epitope which also includes residues in the mid-domain [ 3]. c hGantenerumab has a lower EC50 in our Aβ1-40 binding ELISA, when compared to murine 3D6 (0.34 vs 0.17 pM, respectively) and therefore, clearance of plaques may require more time this is supported by the changes in microglial phenotype and cytokine production.

Together these data indicate that NRR antibodies bind to a conformational epitope on the auto-inhibited conformation of the NRR and prevent adoption of the open, protease-accessible conformation upon ligand interaction.

When a small molecule binds to a NR, a conformational change occurs in the receptor's structure allowing recruitment of the transcription machinery.

PankoMab (Glycotope, Germany) is a murine anti-human MUC-1 antibody that binds to a carbohydrate-induced conformational tumor epitope of MUC-1, greatly increasing its tumor specificity [ 41].

When heparin binds to PF4, a conformational change occurs leading to exposure of neo-epitopes on PF4 and production of antibodies (typically IgG).

Both molecules bound to a distinct conformational state of MDM2 with nM-μM affinities.