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As the growing protein, with the signal sequence at its amino-terminal end, emerges from the ribosome, the sequence binds to a complex of six proteins and one RNA molecule known as the signal recognition particle (SRP).
Similarly, in a DNA tile displacement reaction, an invader tile with a toehold domain binds to a complex consisting of a cover tile and a base tile, initiates a competition with the cover tile for binding to the base tile, and eventually releases the cover tile while itself becoming fully bound to the base tile (Fig. 1b and Supplementary Movie 1).
Because CD36 and CD47 are each known to associate with some β1 integrins, the authors proposed that Aβ binds to a complex of these 3 receptors.
In kidney cells FGF23 binds to a complex of the FGF receptor and Klotho [ 5].
The Pol I promoter, located within the 26-18 S intergenic spacer, binds to a complex of transcription factors [ 18].
14 Nucleation is controlled by a class 3 phosphatidylinositol-3-kinase (PI3K) called vacuolar protein sorting 34 (Vps34), which binds to a complex consisting of Atg6/Beclin-1, p150, and Atg14L.
Similar(53)
For the same previous reason, chemotherapeutic agents can be bound to a complex formed by CNT and antibody against antigen overexpressed on the cancerous cell surface.
In humans, the hGRα, in the absence of glucocorticoids, is present in the cytoplasm and is bound to a complex of proteins.
BMP ligands bind to a complex of transmembrane serine threonine kinase receptors consisting of type I (BMPRIA or BMPRIB) and type II (BMPRII) receptors.
However, as described in yeast, a promoter that has undergone one round of transcriptional initiation remains bound to a complex of general transcription factors referred to as the scaffold or re-initiation complex.
In HIT, antibodies of immunoglobulin G class bind to a complex of heparin and platelet factor 4, resulting in platelet activation and excessive thrombin generation, leading to thrombocytopenia, a hypercoagulable state, and often to thrombosis.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com