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The Staphylococcus aureus multidrug binding protein QacR binds to a broad spectrum of structurally dissimilar cationic, lipophilic drugs.
Haloperidol, a typical antipsychotic, is non-selective and binds to a broad range of receptors, exerting efficacy mainly through the antagonism of dopamine receptors.
DARC binds to a broad range of inflammatory chemokines of both the CC and the CXC chemokine families, but does not interact with homeostatic chemokines (Gardner et al., 2004).
It has been shown that, in the nucleus, β-catenin binds to a broad spectrum of transcription factors other than TCF and LEF and modulates a plethora of downstream targets possibly contributing to cancer stemness and malignancy (Table 1).
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Pasireotide is a novel somatostatin analog that binds to a broader range of somatostatin receptor subtypes (sst) than octreotide.
TFs bind to a broad spectrum of binding sites with different affinity and change targets widely among species.
Thus, p53 phosphorylated at S46 is bound to a broad spectrum of target genes of which the apoptosis genes constitute a specific subset.
TLR2 is expressed on many cell types and has been reported to bind to a broad array of microbial components [67], most notably lipoproteins [68], but also peptidoglycan [35], [69], and recently a bacterial porin [70].
It is well known that LILRB1 and LILRB2 bind to a broad range of classical and non-classical HLAIs [13], [14], [15] and major histocompatibility complex (MHC) class I-like molecules, such as UL18 [16].
LIR-1 has now been shown to bind to a broad range of MHC I molecules.
In contrast, corepressors bind to a broad region of TRs, including the hinge region that is located immediately adjacent to the DBD.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com