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The structure of the SET domain is such that peptide substrates bind on one surface, whereas the AdoMet cofactor binds on the opposite side of the domain.
According to the work from the Bartholomew lab (Dechassa et al. 2008), the ATPase domain binds on the opposite side of the Snf6 binding location on the nucleosome, and we believe that the preferential binding of Snf6 to the relatively open side of the nucleosome eventually leads the SWI/SNF remodeling towards the bound TF.
A similar analysis with the RRM domain shows that PHD3 binds on a site that overlaps with the canonical RNA binding site on the CYP33 RRM domain.
(b) His6-GFP binds on SiO2 QCM crystals coated with 10 mol% PEG-azide and modified with NTA-NO2.
More importantly, we show that Menin binds on the promoter of Inhbb gene where it favours the recruitment of Ezh2 via an indirect mechanism involving Akt-phosphorylation.
Meropenem binds on the active site of CTX-M-15, hydrogen bonded with four common amino acid residues of cefotaxime binding site, as revealed by molecular docking studies.
Similar(17)
We calculated: cell surface bound ON = FA-FC, TIU = FB-cell surface bound ON, TDU = FA-TIU-cell surface bound ON.
The unhappy fellow in the photo was the only one bound on all four feet.
The upper curve is based on the lower bound on R1 in (34).
General bound on the rate of decoherence.
Is there an upper bound on performance?
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