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For example, the human pregnane X receptor (PXR) when crystallized in complex with SR12813, one of myriad xenobiotics to which PXR binds, is observed in three distinct binding sites [33].
The observed lack of significant structural changes when excess nickel binds is consistent with the notion that nickel binding at low-affinity sites enhances NikR's affinity for DNA in vitro primarily through an electrostatic effect.
For a mass of anecdote and detail, however risqué and colourful they might be (and they are often both), does not of itself make for a fully coherent narrative, where the single force that binds is chronology.
Fourth, the original crystal structures from the PDB to which the ligand binds is given.
The recognition element to which a transcription factor binds is of functional significance because DNA may act as an allosteric ligand influencing the conformation and thus the activity of the transactivation domain of the binding protein, as well as the recruitment of other proteins to the enhanceosome.
For example, in [yytm in Jak2] [binds] [the SH2 domain of SHB], yytm is the minimotif sequence, Jak2 is the source protein, binds is the activity, and SHB is the target protein.
Similar(29)
Binding is extremely important.
This bound is strained frequently.
This bound is sharp.
The equivalent bound is (37).
Actually this bound is tight.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com