The AFF4-P-TEFb crystal structure provides a simple and unsuspected explanation—Tat binds in a position to make direct contacts with the scaffold.
Deals like Gemalto's are increasing the European visibility of private equity firms, particularly in France, where government officials seem to intervene regularly in business decisions, and union leaders are often in positions to bind the hands of executives.
A minor, yet frequently found glycan moiety on human serum IgG is bisecting GlcNAc, i.e. GlcNAc bound in β1,4-position to the innermost mannose residue [9].
The promise of "never again" binds anyone in a position to help end a genocide.
A macrolide bound in the tunnel in a position to block the exiting peptide is shown in dark blue.
Interestingly, the second molecule of SAM SAMM #2) binds in a position adjacent to the [4Fe 4S] coordinated SAM #1, and is held in place by five amino acids that are conserved to varying degrees among HemN sequences.
In this new complex, raloxifene binds in a position similar to that observed in the human ERα complex (0.52 rmsd between the two ligands once the proteins are superimposed).
HSA, as the most abundant protein in plasma proteins, is in a position to bind endogenous ligands (e.g., fatty acids, amino acids, hormones, bile acids, metals and toxic metabolites) as well as drugs [15 17].
In mammals, DNA methylation takes place mostly within CpG dinucleotides, where a methyl group that is derived from S-adenosyl-L-methionine is bound in position 5 within the cytosine ring, thus forming 5-methyl-cytosine [ 4, 11].
If the movement were larger, we can identify no weak attachments that would be in a position to quickly bind the target zone.
