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These studies propose that the "closed" non-phosphorylated cortactin form assumes an autoinhibitory conformation where the SH3 domain binds back to an unidentified site within helical proline-rich (HP) domain to prevent binding to N-WASp and other SH3 ligands.
Hence, tTG is not secreted as soluble protein and then binds back to the cell surface and the ECM as proposed earlier [32], but appears first on the outside leaflet of the plasma membrane and only later is translocated to the ECM.
Secreted Asm then binds back to the cell surface to hydrolyze sphingomyelin.
The results of these studies indicate either that secretory lysosomes containing Asm fuse with the plasma membrane and expose Asm (Grassmé et al, 2001; Rotolo et al, 2005; Herz et al, 2009; Xu et al, 2012) or that cells secrete Asm, which then binds back to the cell surface (Schissel et al, 1998a, b).
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Priced at 35 cents and bound back to back with a reprint of "Narcotic Agent," a memoir by Maurice Helbrant, "Junky" sold 100,000 copies in its first year.
"Practically, the system amounted to a form of remuneration for lost slaves," Mr. Rael wrote, "since freed children were often bound back to their former masters".
Within four minutes of leaving the stage after a clipped, predominantly backlit set, the band bound back to perform their signature hit Sex to another sold-out crowd – with singer Matthew Healy eliciting dangerous squeals after stripping down to a black vest.
Each interaction derived from the Homeodomain Resource has been assigned a unique BIND accession number and is hyperlinked from BIND back to the Homeodomain Resource.
When the action descends into pratfalls and Zucker brothers' zaniness (as it does with increasing regularity), the score binds us back to a more melancholic mood, reminding us that beyond all this madness something intangible has been lost.
And in those moments that seemed like the purest of love transpiring between them I also remembered the darker moments when they fought and seemed at such opposite ends of the spectrum that no amount of love could possibly bind them back to one another.
Rather it binds management education back to the regional cultural traditions therefor allowing to overcome a widespread alienation of young business students from their own cultural roots (see contributions in Habisch/ Schmidpeter 2016).
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com