Alternatively, this binding might complement the Ras-PI3Kγ interaction pathway by accepting the allosterically activated PI3K from Ras and enabling it to stay bound at the membrane.
Since tryptophan residues of membrane proteins are known to bind preferentially at the membrane interface, these data suggest that Arb could increase the strength of virus glycoprotein's interactions with the membrane, due to a dual binding mode involving aromatic residues and phospholipids.
APP binding protein-1 (APP-BP1) binds APP intracellularly at the membrane [ 14].
Within maturing fibres of host zebrafish embryos, our analysis reveals a pool of diffusible Dystrophin and complexes bound at the fibre membrane.
β-catenin, a central mediator of the WNT pathway, binds to E-cadherin at the membrane in conjunction with a complex of proteins connecting the adherens junction to components of the cytoskeleton [ 29, 30].
In the case of CCR2, another protein, FROUNT, has recently been shown to bind to the receptor at the membrane and the authors demonstrated that FROUNT is needed for receptor clustering [10].
As predicted from the introduced truncation mutations, immunoprecipitation with an anti-E-cadherin antibody confirmed that ΔN-βcatenin retained the capacity to bind to E-cadherin at the membrane (Fig. S1I).
It seems that this protein has to be bound to the membrane at the expense of losing catalytic residues.
In particular, the product of ORE20/PHO36 specifically binds osmotin at the plasma membrane and controls osmotin-induced cell death via a RAS2 signaling pathway [2].
Chromatin organization may involve the direct binding of inner nuclear membrane proteins and transcriptional machinery, such as the lim domain only 7 (LMO7) protein, a transcriptional activator that shuttles back and forth between the nucleus and cytoplasm and binds emerin at the nuclear membrane [10].
