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This study showed that the receptor binds at the interface of the subunits with three receptor molecules binding to one trimer, with two main sites of interaction on the ligand.
It follows that these Arf-GEFs are predicted in vivo targets for the fungal metabolite Brefeldin A (BFA), an established inhibitor of the secretory pathway which binds at the interface between the Sec7 domain and Arf-GDP in vitro [17], [18].
ATP binds at the interface of the two NBFs, which induces the formation of a closed dimer.
In this model, the peptide binds at the interface of the inner and outer domains, preventing folding of the bridging sheet and formation of the coreceptor binding site.
We currently only have molecular insights into the inhibitory mechanism for Kinesin-1, where one C-terminus binds at the interface between two motor domains to inhibit the molecular motor (Hackney et al., 2009; Kaan et al., 2011).
Kinesin-1 is regulated through an auto-inhibitory mechanism whereby one C-terminal tail binds at the interface of the two motors, such that it creates a second point of attachment in addition to the coiled coil region.
Similar(51)
Many biochemical studies support the view that the juxtaposed G- and T-segments bind at the interface of the B'/A' DNA binding and cleavage core and the ATPase domains [1].
In chain A, the FAD is noncovalently bound at the interface of a Rossman-type domain and the substrate-binding domain.
Benzodiazepines bind at the interface of the α and γ subunits on the GABAA receptor.
FK506 is known to bind at the interface of FKBP12 and calcineurin [27].
Rapa is known to bind at the interface between FKBP12 and TOR, resulting in TOR inhibition [26].
More suggestions(20)
initiates at the interface
binds at the boundary
ions at the interface
binding at the interface
binds at the promoter
binds at the dyad
binds at the C-terminus
binds at the binding
binds at the membrane
binds at the interphase
binds at the protein
binds at the colchicine
binds at the 3′-end
binds at the tip
binds at the junction
binds at the back
binds at the β-cleft
binds at the top
binds at the cell
binds at the A-site
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