Sentence examples for binds at the active from inspiring English sources

The structural analysis reveals that the side chain of residue Asp287 in rPPEWT would have a potential steric conflict with (S -AcO-CPA when the S -AcO-CPAbindS -AcO-CPActive site of the enzyme.

The structures suggest overlapping binding sites for the substrates d-glyceraldehyde-3-phosphate (d-G3P) and l-arginine, and are consistent with the proposed CEAS mechanism in which d-G3P binds at the active site and reacts to form an α,β-unsaturated intermediate, which subsequently undergoes (1,4 -Michael addition with the α-amino group of l-arginine.

The reactive site loop (RSL) of domain 1 of CrSPI-1 (Cys1 to Lys6) binds at the active site region of subtilisin from P3 (Cys1) to P3' (Lys6) in a substrate-like manner (Fig. 4A, panel 1).

The result of these simulations suggested that 2 binds at the active site of BoNTA endopeptidase in a manner similar to that of 1 and that the hydroxyl group attached to the phenyl group of 2 indeed has hydrogen bonds with Arg362 and Asp369 of the endopeptidase (Figure 2).

Gleevec is a multikinase inhibitor that binds at the active site of tyrosine kinases.

Furthermore, ADP binds at the active site with only one magnesium ion, termed Mg2 from previous structures.

The ferrous ion bound at the active sites is essential for the activity of hydroxylases.

ITC shows that PatE2 C51A binds almost as tightly as PatE2, but as the internal cysteine is processed extremely slowly, we conclude this binding is non-productive; the Ala at position 51 is bound at the active site.

While in XDH the two residues seem to determine which substrates are efficiently bound at the active site, in mAOX1 more factors determine the binding and conversion of substrates.

Specifically, the effect of KCl concentration on HDAC8 activity was investigated by Fierke and co-workers using HDAC8 with two different divalent metal ions (Co2+ and Zn2+) bound at the active site.[ 5] These experiments revealed a bell-shaped activity profile, with an activating effect at lower concentrations of K+ and an inactivating effect as the concentration was increased.

In general, SODs have a strict metal binding specificity for enzymatic activities with the exception of a class of enzymes which show enzymatic activity regardless of whether Fe or Mn is bound at the active site; these are known as cambialistic forms [ 2- 5].