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Whereas no mammalian partner was thus far associated with the PDZ-binding motif of NleH1, a previous report demonstrated that EspI binds a number of PDZ-containing proteins, including NHERF1 and NHERF2 (Lee et al., 2008).
Chp binds a number of effector kinases including PAKs [26], [27] and is reported as an early expressed neural crest marker in Xenopus [28].
The −10 region is capable of enhancing luciferase expression under the control of both the SCL pro1a and SV40 promoters in human erythroid cells and the endogenous −10 binds a number of transcription factors including GATA1, E2A and LDB1 in vivo.
HA binds a number of ECM proteins, including fibronectin, as well as cell surface receptors, including CD44.
They identify a protein kinase, ULK3 that binds a number of components of the ESCRT III com-lex.
Indeed, the multidomain Pins binds a number of other proteins, including the microtubule anchoring protein NuMA [ 20].
Similar(43)
N-terminal sequences are thought to bind a number of partners (Beland & Roucou, 2012), with binding of Cu II) and Zn II) ions by the OR being an area of active interest (reviewed in Millhauser, 2007).
Our hypothesis is that if the TF is active in a tissue, it will bind a number of target sequences, thus the putative TF binding sites will be overrepresented in the DNase HS regions (see Methods for details).
The E2661-HATMCT chimeric glycoprotein was able to bind a number of conformation-dependent monoclonal antibodies and a recombinant soluble form of CD81, suggesting that it was folded in a manner comparable to "native" E2.
SpA is a multifunctional protein that has been shown to bind a number of ligands including IgG and Tumour Necrosis Factor Receptor1 (TNFR-1).
Following a proteomic approach, we have found that B. anthracis spores bind a number of human serum proteins that are involved in humoral and innate immunity.
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