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Because heparin binds a broad spectrum of growth factors, this delivery platform is expected to offer controlled release of many growth factors with retention of bioactivity.
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It has to be kept in mind that the use of organoclays as feed additives is not permitted in the European Union, but since organoclays are known to bind a broad spectrum of substances they were included in this study.
Although these receptors bind a broad spectrum of HLA-I alleles, they have a higher affinity for HLA-G 16, particularly in its dimeric form 18, 20.
Candidate receptors for HDL endocytosis in macrophages are the scavenger receptors SR-BI, CD36 and SR-A, which bind a broad spectrum of ligands as well as ABCG1, although the presence of this receptor at the plasma membrane has been questioned recently [88].
Several viral proteins were reported to bind a broad spectrum of mediators of the immune system, including fractalkine [ 8]. Specific gene polymorphisms have been reported to be risk factors for coronary heart disease [ 10] and deletion of CX3CR1 in apolipoprotein E deficient mice reduced atherosclerotic lesion formation [ 10].
The Staphylococcus aureus multidrug binding protein QacR binds to a broad spectrum of structurally dissimilar cationic, lipophilic drugs.
It has been shown that, in the nucleus, β-catenin binds to a broad spectrum of transcription factors other than TCF and LEF and modulates a plethora of downstream targets possibly contributing to cancer stemness and malignancy (Table 1).
TFs bind to a broad spectrum of binding sites with different affinity and change targets widely among species.
Thus, p53 phosphorylated at S46 is bound to a broad spectrum of target genes of which the apoptosis genes constitute a specific subset.
These results suggest that the HBV core protein might bind to a broad spectrum of human gene promoters, especially those featuring high CpG density.
Further adding to the complexity of targeting transcriptionally competent β-catenin is the fact that β-catenin can bind to a broad spectrum of transcription factors other than TCF/LEF.
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