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It was previously reported [20], [32] that LILRB2 binds a broad range of classical HLAIs HLA-A*1101 HLA-A*1101 -C*0401, and -Cw*0702) with andinities (Kd) ranging from ∼14 to ∼45 µM and also binds a non-classical HLA (HLA-G1) with affinitiesffinity (Kd≈5 µM).
Because it contains 310 helices region located between the C and E strands of D1 and a hydrophobic core consisting of the helices and C and E strands, LILRA3 D1 can binds a broad range of classical and non-classical HLAIs.
D6 on the other hand, binds a broad range of CC chemokines including most agonists of CCR1, CCR2 and CCR5 (Bonecchi et al, 2004).
D6, an important member of the decoy receptor family, binds a broad range of CCR1, CCR2, and CCR5 ligands, prevents excessive infiltration of classical monocytes and neutrophils into the myocardium in a mouse model of myocardial infarction (Cochain et al, 2012).
We focused our attention on the upregulation of the HtrA1 gene, because its protein product binds a broad range of transforming growth factor (Tgf)- β family proteins (e.g., BMP4, BMP2 and Tgf- β1), which have critical roles in neurogenesis modulating either cell proliferation or cell survival.
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Such a T cell helper peptide must be promiscuous in its ability to bind a broad range of MHC class II alleles due to broad allelic variation in the human population.
The role of CD36 in these processes is attributed to its ability to bind a broad range of ligands [5].
p21Cip1 can bind a broad range of cyclin-CDK complexes, with a preference for those containing CDK2 (reviewed in [31], [45], and during a normal cell cycle, facilitates active cyclin-CDK complex formation to promote cell proliferation.
The protein has been proposed to serve multiple functions, including endocytosis of various immunoglobulins [ 25] and mediation of L-selectin-dependent lymphocyte rolling [ 26], and has been shown to bind a broad range of polar lipids [ 27].
Haloperidol, a typical antipsychotic, is non-selective and binds to a broad range of receptors, exerting efficacy mainly through the antagonism of dopamine receptors.
DARC binds to a broad range of inflammatory chemokines of both the CC and the CXC chemokine families, but does not interact with homeostatic chemokines (Gardner et al., 2004).
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