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Exact(2)
In such a scenario, TF binding would be determined not only by the presence and strength of DNA motifs but also by the cobinding of other TFs to open a DNA-binding region.
The chemistry of INH and AcHz oxidation is similar; therefore, their relative contribution to covalent binding would be determined by the relative rates of acetylation, hydrolysis, the affinities of P450 isozymes for the two hydrazides, and the relative contributions of other clearance pathways such as pyruvate conjugation.
Similar(58)
The rate would be determined by the sum of both homotypic and heterotypic binding.
We agree adding a control antibody to eliminate FcR binding would be an informative approach to determine if the mechanism is via blockage of the interaction of CD47 with SIRPa, however, as the reviewers have already described, Willingham and colleagues did not use this approach.
And how exactly would "desecration" be determined?
I would say, to be determined.
And how would the winner be determined?
HER2 binding affinity was determined in saturation radioligand binding assays using SKBR-3 cells (1.3 × 106 HER2/cell).
The dynamic binding capacity was determined.
The binding kinetics was determined by SPR.
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