Sentence examples for binding with the target from inspiring English sources
k a slide k a D = 0 = 1 + 2 s 1 + 2 s (1 − p bind ) / (1 + 2 s 2 p bind ) pbind is the probability of binding with the target site in each nonspecific encounter and is dependent on the microscopic rate constant associated with the recognition of a target site.
The dihydroquinazolinone molecules were designed on the basis of fragments responsible for binding with the target enzyme.
Moreover, too flexible compounds are not attractive from the point of rational drug design as they lose on their drug-likeness, due to a low expected biological availability after oral intake and large entropic penalties upon binding with the target macromolecule.
A labeling probe containing a pyrenecarboxamide-tethered modified DNA base, PyU, has been developed for fluorometric detection of RNA poly(A) tracts, in which the fluorescence emission intensity was controlled by the microstructural change around PyU caused by binding with the target RNA.
For efficient binding with the target enzyme furin, we propose that such above moiety must carry a furin recognition peptide sequence.
Firstly, it allows identifying new molecular groups providing main contribution to new inhibitors binding with the target protein.
The phenomenon of nucleotide bias might be concerned with the mechanisms of miRNA action, such as binding with the targets for gene regulation.
The phenomenon that most A and U were distributed in the front of reads with G and C being focused on the 6-18 positions might be concerned with the mechanisms of miRNA action, such as binding with the targets for gene regulation.
Their binding mode with the target enzyme was clarified by molecular docking.
Furthermore, there is no means to incorporate protein-specific information which additionally captures interaction details of different experimentally observed binding modes with the target protein under consideration.
For example, sgRNA with a truncated base-pairing sequence (17 nt instead of 20 nt) enhanced the targeting specificity because truncated sgRNAs have reduced binding affinity with the target DNA and thus are more sensitive to mismatches (Fu et al., 2014).
