Sentence examples for binding with the enzyme from inspiring English sources

Comparison of the ligand binding with the enzyme in the crystal structure of NMT and that proposed by the phamacophore is consistent.

Aiming to render adequate functional groups to the covalent binding with the enzyme the POS PVA matrix was chemically modified using epichlorohydrin.

Some compounds have a good activity against InhA and in particular, compounds 12r, 13b and 13r exhibited more than 60% binding with the enzyme even at 5 μM (exhibited good IC50 upto 2.4 μM).

Our results showed that the cyclization involving a C-terminal carboxylic acid (head-to-tail or side chain-to-tail) led to compounds with significantly diminished inhibitory potency towards PACE4, indicating that an appropriate balance between rigidity and flexibility of the structure is necessary to allow the optimal binding with the enzyme.

Equilibrium constants have been determined for Hg2+ binding with the enzyme or the enzyme-substrate complexes (Ki =0.012 μM).

The kobs/[I] parameter is valid as long as the inhibitor does not saturate binding with the enzyme (in which case kobs = kinact).

The dissociation constants for inhibitor binding with the free enzyme and the enzyme-substrate complex, Ki and αKi, were obtained from the double-reciprocal plots and the replots of the slope and the vertical intercept versus the concentration of CC-EO (Figure 2B, 2C) or trans-cinnamaldehyde (Figure 3B, 3C), respectively.

However, other binding contacts with the enzyme or DNA substrate can mediate drug binding in a manner that is not optimal for inducing DNA cleavage.

The QM/MM simulation using this alternative substrate binding mode was, in contrast, quite stable and underscored several important binding interactions with the enzyme.

Finally, molecular modeling studies were performed through docking of the synthesized compounds in the HCV NS3/4A protease active site to assess their binding modes with the enzyme and gain further insight into their structure-activity relationships.

Modeling of these inhibitors revealed the same overall binding mode with the enzyme as triclosan, but the B-ring modifications have additional interactions with the strongly conserved Asn130.