These peptides also showed very good binding with major carrier proteins of blood, the serum albumins.
The dipeptides showed very good binding with plasma carrier proteins of both bovine and human.
Similar studies have been carried out by Valerio et al. [25], and they have suggested that when higher enzyme concentration is immobilized, the binding sites of the carrier get saturated with enzyme which further leads to diffusion limitation phenomena.
An example is the relative alkylation index (RAI), which estimates a compound's relative degree of covalent binding with host carrier proteins (Roberts et al., 2007a, 2009).
Electrostatic interactions, hydrophobic attractions, and covalent bindings are the mechanisms allowing attaching the drug with the carrier.
The free analyte in the sample competes with the carrier protein bound analytes for antibody binding sites at the test line.
Upon receiving a request for interconnection, services, or network elements pursuant to section 251 of this title, an incumbent local exchange carrier may negotiate and enter into a binding agreement with the requesting telecommunications carrier or carriers without regard to the standards set forth in subsections (b) and (c) of section 251 of this title.
Cell cultures were incubated with the carriers and the binding (at 4°C), uptake (at 37°C), and degradation were determined with radioactive and immunohistochemical methods.
The pace of binding correlates with carrier avidity, concentration, perfusion rate, and the density of binding sites.
For widespread use in medicine of any radioisotope, two factors are essential: availability of the isotope and a stable and effective mode of binding with an appropriate chemical carrier [ 4].
