Comparison of domain structures of canonical clock proteins revealed that, like Daphnia, EpPER has a CK1 binding region with similarity to mouse PER1 and Drosophila PER [ 14, 15].
In a genetic screen for regulatory factors of the glucosinolate homeostasis in Arabidopsis thaliana [ 35], we have recently identified a gene coding for a calmodulin-binding protein with similarity to SF16 from sunflower [ 36].
It turned out that Tarp is a nucleator of actin since it contains several actin-binding domains (ABD) with similarity to WH2 domain proteins.
Furthermore, the fungal chitin-binding domain CBM18 and uncharacterized domains with similarity to carbohydrate-binding domains are present in some LPMO proteins [ 27].
FUS, TDP-43 and other RNA binding proteins (RBPs) contain domains with similarity to yeast prion domains (Figs. 1, 2).
The FLOWERING LOCUS T/TERMINAL FLOWER 1 (FT/TFL1) gene family encodes proteins with similarity to phosphatidylethanolamine binding proteins which function as flowering promoters and repressors [ 75].
Here we provide evidence that CAF-1 and STICHEL (STI), which encodes a protein with similarity to ATP-binding eubacterial DNA-polymerase III-subunits [ 49], together control trichome differentiation in an endoreduplication-independent pathway.
Seven of these sequences contain an N-terminus domain with similarity to prokaryotic periplasmic binding proteins (PBPs), which are involved in amino acid and nutrient transport in bacteria and are considered to be the origin of the class C GPCR ligand binding domains [ 26].
P-values for two SNPs, both from the same locus (AY108077, in IBM2 Bin 6.04, with similarity to a calmodulin-binding heat-shock protein), were the only ones that were significant using a Bonferroni-corrected critical value of 0.05/847 = 0.000059.
The development of tpp1− cells is strongly impaired in the presence of the lysosome-perturbing compound chloroquine, and this phenotype can be suppressed through a secondary mutation in a gene that we name suppressor of tpp1− A (stpA), a gene encoding a protein with similarity to mammalian oxysterol-binding proteins (OSBPs).
