Sentence examples for binding with high affinity from inspiring English sources

Aydin et al. describe a boomerang-shaped structure for IZUMO1, and their data suggest that IZUMO1 undergoes a major conformational change on binding with high affinity to JUNO.

p19 exhibits size-specific and sequence-independent binding of its small RNA ligands, binding with high affinity to duplexes 20 22 nucleotides long.

In addition few small molecular inhibitors such as flavonoids have also been developed which are capable of binding with high affinity to IL-4Rα and, therefore, can be very effective in blocking IL-4-mediated responses.

Accordingly, protein sequences from influenza A virus strains currently in circulation (H1N1, H3N2), agents of past pandemics (H1N1, H2N2, H3N2) and zoonotic infections of man (H1N1, H5N1, H7N2, H7N3, H7N7, H9N2) were evaluated for the presence of amino acid sequences, motifs, that are predicted to mediate peptide epitope binding with high affinity to the most frequent HLA-DR allelic products.

Aptamers are synthetic oligonucleotides that have undergone iterative rounds of in vitro selection for binding with high affinity to specific analytes of choice; a sensitive yet simple method to utilize aptamers as recognition entities for the development of biosensors is to transduce the signal electrochemically.

Previous results indicate two receptor populations: one binding with high affinity (10 100 pM) and one with low affinity (1 10 nM) [2].

These observations suggest that contacting residues involved in peptide-mediated interactions have been selected through evolution on two different bases: those in the motif to ensure binding with high affinities, and those in the context to maximise specificity against other potential binders and prevent cross-reaction with homologous proteins.

We found that the c-Myb DNA-binding domain can bind with high affinity to NrasI and NrasII, but with a reduced affinity to NrasIII.

A ligand can shift a protein's folding/unfolding equilibrium by binding with higher affinity to the native state.

Specifically, nuclear proteins were found to be binding with higher affinity to the 129B6 polymorphic site.

Greater loss of water at the interaction interface of the DNA calls for binding with higher affinity, eventually distorting the DNA to a greater extent accounted by the change in major groove width and DNA tilt, stretch and rise.