Sentence examples for binding with a wide from inspiring English sources

PAR is the most electronegative biopolymer and this property is essential for its binding with a wide range of proteins.

Aptamer is single-stranded nucleic acid (DNA or RNA) ligand that usually possesses high affinity and results in a significant conformation change upon binding with a wide range of targets.

Urbaniak et al. used a kinase-inhibitor matrix (kinobeads) that can measure a compound's binding interaction with a wide variety of kinases simultaneously, to profile the known mammalian kinase inhibitors staurosporine (10) and BMS-387032 (11, Figure 3), along with four parasite kinase inhibitors identified by the University of Dundee's Drug Discovery Unit (structures not disclosed).

Lactoferrin is an iron-binding glycoprotein with a wide spectrum of biological activities (Ann Rev Nutr 1995, 15:93).

The HRDC domain is responsible for regulating DNA-binding affinity with a wide variety of DNA substrates [ 5].

In the bacterium Escherichia coli the transcriptional regulation of gene expression involves both dedicated regulators binding specific DNA sites with high affinity and also global regulators – abundant DNA architectural proteins of the bacterial nucleoid binding multiple sites with a wide range of affinities and thus modulating the superhelical density of DNA.

Also interesting is the basic residue found at position 115 which, similarly to Arg115 in class III enzymes [ 73], could contribute to a substrate-binding site with a wider entrance and higher volume.

Since the pharmacological properties (experimental radioligand binding assay) are variables with a wide numerical distribution, for plotting purposes, we have reported them as −log of the K i or IC50 (i.e. as pK i or pIC50).

Intriguingly, genes containing AP2-Sp binding sites are associated with a wide range of biological processes, such as sporozoite formation, host cell invasion or liver stage development.

The results showed that the binding selectivity changed little with a wide concentration range.

Collagens contain multiple binding sites that interact with a wide range of extracellular and cell surface proteins thought to be linked to pluripotency, including various integrins and HSPGs [reviewed by [ 54].