Employing a combinatorial phage peptide library, we previously identified the peptide MRYYESSLKSYPD (designated, library-peptide) that binds the snake toxin α-bungarotoxin (α-BTX) with a moderate binding constant of 10−6 M (Balass et al., 1997. Proc. Natl. Acad. Sci. USA 94, 6054 6058).
According to the model, in genes with very low binding to NRSF, a moderate increase of NRSF levels would not alter repressor binding appreciably.
A hexahydropyrazinoquinoline (compound 5c) was previously discovered as a novel D3 ligand with a moderate binding affinity to the D3 receptor (Ki = 304 nM) but no selectivity over the D1-like and D2-like receptors.
Olanzapine, an antipsychotic with an intermediary D2R binding affinity, induces a moderate elevation of PRL levels [ 200, 244].
We have shown for the first time that recovered patients have persistent and robust binding as well as neutralizing antibody and CTL responses throughout the study period with a moderate decline one year after the onset of symptoms.
We found significant binding motifs for OsSMF1, including ACGT (CCACGTCA), with a high intensity of 13,715, GCN4 (TGAGTCA) with a moderate intensity of 7,639, and ATGA (GGATGAC) with an intensity of 6,463 (Fig. 2a, c and e).
Here we reported that Rps27l is indeed a ribosomal protein, whose depletion triggers ribosomal stress (as evidenced by B23 nucleoplasm staining and enhanced RPs-Mdm2 binding) with moderate reduction in ribosomal RNA processing, but no effect on general protein synthesis.
