We also noticed that some DNA motifs were negatively associated with binding of some TFs, which may indicate the inhibition of DNA binding.
Moreover, recent bioinformatics analysis of protein sequences for 330 bona fide SH2-binding motifs revealed that tyrosine phosphorylation sites in human proteome are significantly enriched in the vicinity of the SH2 domain-binding sites [ 84], which may indicate that processive phosphorylation is a rather common phenomenon.
All hits of the partial agonists had one proper hydrogen bonding interaction except (S -6-OH-DPAT, which may indicate different binding modeS -6-OH-DPAT
So, we integrated a control for the length bias and found that there is no significant correlation between the density of miRNA binding and the protein evolutionary rate, which may indicate that change of the number of regulatory miRNAs for genes is mainly achieved by change of its 3'UTR length and requires no change of binding site density.
The amino acid that is changed in our Plexin-B2E369mutant is localized in the Semaphorin-binding domain of the protein (Fig 5F), which may indicate that the glutamic acid at this position is essential for the binding of these Semaphorins to the cell surface receptor Plexin-B2.
The amino acid sequences of AP2/ERF transcription factors contained many conserved motifs which may indicate potential DNA-binding sites or participate in activating the specific function of AP2/ERF genes.
Other novel APC targets were chromatin binding protein 4B (CHMP4B), and p300/CBP-associated factor (PCAF), which may indicate a role of APC in the epigenetic control of gene transcription.
As previously mentioned, the main feature of J-domain proteins is a highly conserved HPD motif, which may indicate its importance in binding to DnaK.
The hydrophobic particles also appear to retain the most salivary proteins after the two SDS elutions, which may indicate that this hydrophobic binding is a more important interaction in the oral cavity with regards to pellicle formation.
Some of them exhibit a higher binding affinity to ER β than to ER α which may indicate that they have different pathways for their actions and explains tissue specific changeability in phytoestrogenic action [ 85].
