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The high-resolution binding site data from a large number of RBPs will benefit investigations on the coordination and competition of RBP binding, which has not been extensively studied.
In addition, each of them also possesses an N-terminal C2 domain (Protein kinase C Conserved region 2; phospholipid binding), which has not been reported previously in Metazoan myotubularins.
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The present structure reveals that tankyrases contain a short zinc-binding motif, which has not been predicted.
Ideally, tumor selectivity of these oncolytic viruses is already determined during viral cell binding and entry, which has not been reported for melanoma.
The VTD binding residues of the model peptide were identified using the NMR titration experiments with VTD, including a newly discovered VTD binding residue Leu14 (μ1-L1580 in Nav1.4), which has not been reported by point mutation studies.
The reason is mounted silver on the support, which has not strong binding with the support.
These observations highlight the importance of kinetic binding analysis for studying disease-associated HIF-2α mutations, which has not been previously reported.
The arbitrators' final ruling, which has not been issued, would be binding, but the union, the Patrolmen's Benevolent Association, has filed a list of objections, and one union strategist said leaders are still hoping to win a larger raise.
But there are weak spots in a fragile deal which has not been directly signed by the Syrian warring parties and is less binding than a formal ceasefire.
In parasitic platyhelminthes (flatworms) there is an unusual family of calcium binding proteins which have not been found in any other group of organisms.
In addition, the HIF-1α and PHD1 promoters contain NF-κB-binding sites, which have not been functionally characterized.
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