A variant, rs4820599, on the GGT1 gene is predicted to be located at a transcription factor binding site, which can result in differential gene transcription, according to FuncPred (http://snpinfo.niehs.nih.gov/snpinfo/snpfunc.htm, accessed 3/31/2015).
The same domain can bind different ligands in the PFAM dataset, which can result in different binding site conformations.
Its disadvantages are nonspecific binding to the size-exclusion material, which can result in false positives or negatives, and that reusability of the columns is significantly reduced when more complex protein matrices are researched.
Arrestin binding promotes receptor internalization by endocytosis, which can result in ubiquitination or recycling of the GPCR (Pierce et al. 2002; Gurevich VV and Gurevich EV 2006; DeWire et al. 2007).
Nucleotides in loops II and III may interact with each other ('kissing hairpins') or with ribosomal proteins, which can result in altered binding of ribosome to IRES and, consequently, affect translation through a 'zipper' mechanism (41).
Specific 5hmC-binding proteins have been identified, some of which can result in altered chromatin structures and gene expression.
AR gene rearrangement is a mechanism of CRPC progression which can result in constitutively active truncated AR splice variants that lack the AR-ligand binding domain.
Flexible and combinatorial binding of TFBS can result in computational binding profiles of low specificity, which is the cause of difficulties with identification of regulatory regions embedded within long candidate regions [ 24].
MYT1/MYT1L binding can result in the recruitment of histone deacetylases (HDACs) to target gene promoters, which results in transcriptional repression [15]; the resultant loss of MYT1 function may be compensated by MYT1L activity [16].
The probes of detecting liver fibrosis ought to have the capability of specifically targeting and binding ECM, of which excessive accumulation can result in fibrosis.
