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This provides useful information for further development of more potent compounds towards FGF-2 binding, which can have potential applications in wound healing and anticancer therapy.
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In natural proteins, which can have weaker binding affinities for the same coordination motifs, the difference may be due to the loss of Zn II) binding energy to protein folding.
Clade I is dominated by CBM5 and 12 domains, which are primarily chitin binding, but possibly can have a lignin-binding function as well [ 44].
Binding events can have one or two gene/protein themes.
variable bindings can have attached declarations.
This is of special relevance as FN has many cryptic binding sites which can be unmasked and exposed by sGAG binding31,44,51.
In addition, we have also identified 10b, a tight binding fragment, which can be use for fragment-based drug design purposes.
An Aβ-binding compound, which can be radio-labelled by F, has also been developed.
Computer simulations have shown that this is indeed the case for eukaryotic transcription factor binding sites, which can appear neutrally within microevolutionary timescales [13].
S100A1 encodes an intercellular calcium-binding protein, which can control myocardial contractility [ 38] and has recently been identified as an important SOX9 regulated gene that controls the terminal differentiation of chondrocytes [ 29].
ETV1, ETV4 and ETV5 have highly conserved COP1-binding motifs, which can recognize COP1 [ 17, 22].
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